In non-seminoma tissues and cell lines, maintenance- and de novo- methylation seem to occur in parallel, indicated by expression of DNMT1, DNMT3B and DNMT3L. In line with this, comparable DNMT1 expression levels between seminomas and non-seminomas and strong DNMT3B expression in ECs, but not seminomas have already been demonstrated [41], [33], [54]. The gene discussed is DNMT3L; the disease is seminoma.