In our experimental conditions, OM-85 did not significantly enhance the secretion of other pro-inflammatory, antiviral and chemotactic mediators, such as TNF-α, IL-1β, IFNβ1, IL-12, IL-23, APRIL, CCL4, CCL19 and CXCL10 (Figure S1D and not shown). The gene discussed is IFNB1; the disease is ocular melanoma.