However, nodal status showed that whilst Nectin-1 and -4 were increased in node positive tumours (Nectin-1 node negative 189+/−42, node positive 466+/−214; Nectin-4 node negative 0.149+/−0.10, node positive 0.38+/−0.25), both Nectin-2 and -3 were reduced (Nectin-2 node negative 154+/−130, node positive 11.1+/−9.1; Nectin-3 node negative 2458+/−1761, node positive 425+/−198), Figure 1A and B. This evidence concerns the gene NECTIN1 and neoplasm.