Nectin-1 was found to have higher expression with increasing NPI (Nottingham Prognostic Indicator), tumour grade and TNM status (tumour-nodal involvement) as was Nectin-4 (Nectin-1: NPI1 188.7+/−42 versus NPI3 560+/−500; Grade1 191.3+/−78.5 versus Grade3 1313+/−1051; TNM1 266+/−45 versus TNM3 1313+/−1051, Nectin-4: NPI1 0.149+/−0.104 versus NPI3 0.323+/−0.201; Grade1 0.0265+/−0.024 versus Grade3 0.252+/−0.2; TNM1 0.00001+/−0.000 versus TNM3 0.252+/−0.24). This evidence concerns the gene NECTIN4 and neoplasm.