Although it is still not clear how stromal cells create their microenvironment and promote PR signalling to reach the adjacent tumour cells, one can assume that stromal PR-mediated regulation of molecules such as IGFBP-1 [37, 38] contributes to the inhibitory effects of progesterone in uterine tumours via a paracrine mechanism. The gene discussed is IGFBP1; the disease is tumor of uterus.