TGFB1 and cervical squamous intraepithelial neoplasia: Moreover, CIN-derived MSCs displayed defective growth potential, as evidenced by defective clonogenic capacity, increased doubling time, and decreased proliferation, which could not be attributed to either increased cellular apoptosis or increased TGF-β1 production: a TGF-β1 neutralizing antibody could not restore the impaired clonogenicity in patient MSCs.