PDE1A and neoplasm: Significantly, a number of genes with positive correlation with tumorigenicity such as Akap13, CSF1, Grip1, JunB, Nexn, Nob1, Nrf2f2, Pcsk2, Pde1a, Pomgnt1, Radil, Usp5 and Wnt2 had previously been shown to have oncogenic, growth-promoting or pro-angiogenic activities [38]–[54] while several genes with negative correlation with tumorigenicity such as Calr, Dpp8, Fbln1, Hsd3b1, Mxd4, Pten and Mrpl41 had previously been shown to have tumor suppressive, growth inhibitory, proapoptotic or immune regulatory activities [55]–[63].