However, inhibition of the APC by pUL21a and pUL97 [7], [8], along with our present data showing that pUL21a can mediate cyclin A degradation in the absence of its APC recognition motif (D-box), suggests that cyclin A degradation during HCMV infection is APC-independent. This evidence concerns the gene CCNA2 and cytomegalovirus infection.