In de novo AML patients, a highly significant positive correlation was found between NRP-1 percentage expression and total leukocyte count (TLC) (r= 0.577, p=0.005), and a negative correlation was seen between NRP-1 percentage expression and hemoglobin (Hb) levels (r= -0.534, p=0.01), with no significant correlation found between NRP-1 percentage expression and any other parameters including age, platelet count, lactate dehydrogenase (LDH), PB blast %, CD33, CD13, CD14, CD117, CD61, myeloperoxidase, CD2, CD5, CD7, CD34, HLA-DR, CD10, and survival time. The gene discussed is CD34; the disease is acute myeloid leukemia.