In 20% (n=12) of the patients that completed the study, a bleeding disorder was detected (1 case of type 3 VWD, 2 cases of low VWF:Ag, 1 case of probable VWD, 3 of BSS, 2 of GT, 2 of ITP, and 1 of congenital factor VII deficiency). This evidence concerns the gene VWF and von Willebrand disease (hereditary or acquired).