The majority of patients with postpartum AHA have low-titer FVIII inhibitors, which tends to disappear spontaneously after a median period of 30 months [4,8]; however, high-titer postpartum FVIII inhibitors may persist for years despite immunosuppressive therapy and may precede the development of an overt autoimmune disease [4]. This evidence concerns the gene F8 and autoimmune disease.