In thepresent study we examined the transcription factor genesLMO2, LYL1, TAL1, TLX1, TLX3, and BMI1, and gene fusionof CALM-AF10 in an effort to identify T-cell-specificoncogenic transcription factors and their association withprognosis in pediatric T-ALL patients. The gene discussed is TLX3; the disease is acute lymphoblastic leukemia.