F8 and von Willebrand disease (hereditary or acquired): Type 2Nmutations occur primarily between exon 18 and 20 [41];95% of the mutations are missense mutations (Figure 6).R816W and R854Q are the most common type 2N mutations.Type 2N mutations are highly penetrant and thelevel of FVIII in type 2N vWD patients is associated withthe specific mutation.