Because lower levels of CD4+ FoxP3+ Treg cells have been found to relate to an increased risk for myocardial infarction in subjects with no coronary artery disease in a prospective cohort study [32], the exact meaning of that decrease in both CD4+LAP+ and CD4+CD25+ Treg cells in ACS should be further investigated. Here, CD4 is linked to coronary artery disorder.