The NFκB signaling may regulate the expression of CXCR4 in ovarian carcinoma by multiple mechanisms, including those involving three-dimensional collagen type I (as a model of the ECM present at the metastatic sites) and via loss of the breast cancer metastasis suppressor 1 (BRMS1) [67,69]. The gene discussed is CXCR4; the disease is ovarian carcinoma.