High grade serous ovarian cancer (HGSOC), the deadliest type of the disease [62], contains focal genomic amplification of the CXCR4 gene locus along with the mutations in TP53, suggesting that those may be some of the early events in the development of HGSOC, and they could contribute to chromosomal instability of ovarian carcinoma cells [63]. The gene discussed is CXCR4; the disease is ovarian carcinoma.