These data indicated that the fractalkine axis in ovarian carcinoma could play a major role in regulation of peritoneal adhesion, further suggesting that abrogation of the CX3CL1/CX3CR1 interaction in ovarian carcinoma may reduce metastatic burden by blocking formation of the secondary lesions by preventing attachment and adhesion of the metastasizing cells to the organs and tissues of the peritoneal cavity. The gene discussed is CX3CR1; the disease is ovarian carcinoma.