Analyses of the specific triplet LBP, TLR and IL-6 showed LBP A + TLR B + IL-6 A and LBP B + TLR A + IL-6 A combinations (P = 0.006; P = 0.012, respectively) to be at high risk for sepsis development, but occurrence of the proposed variants was low (4.2 and 4.8% of patients). The gene discussed is IL6; the disease is Sepsis.