A high-risk combination for sepsis development and typical for the patients group was the quintet of wild-type homozygotes (P = 0.005), but the most common specific combination in the three studied groups was BPI A + LBP A + TLR A + HSP 70 A + IL-6 B. This combination also represented high risk for sepsis development (P = 0.016). The gene discussed is BPI; the disease is Sepsis.