INS and hypertensive disorder: The first descriptions of the association between T2DM, hypertension and dyslipidemia dates from 1920; but it was Reaven in 1988, who suggested for the first time that these factors tended to occur in the same individual under the form of a syndrome “X”, which included five components: resistance to glucose uptake mediated by insulin, glucose intolerance, hyperinsulinemia, elevated triglycerides, decreased HDL cholesterol and hypertension; all five components were associated with an increased risk of coronary heart disease [12].