Similar neuroprotective effects mediated by several SIRT1 activators were previously demonstrated in two different EAE models of MS, relapsing/remitting EAE in SJL/J mice [23,24] and chronic EAE in C57BL/6 mice [22], but the mechanism of these effects was not assessed beyond the role of activating SIRT1. The gene discussed is SIRT1; the disease is myeloid sarcoma.