TCHP and cancer: Hypoxia-inducible factor-1 (HIF-1), the major transcription factor involved in regulating the adaption of cells to hypoxic conditions, also regulates the expression of many glycolytic genes[12] and can be activated in cancers even under normoxic (or pseudohypoxic) conditions in response to oncogenic signaling pathways or mutations in tumor suppressor proteins[13,14].