Notably, ESCC patients showing nodal positivity and MEKK3 overexpression had significantly reduced median DFS = 9 months in comparison node negative patients with low MEKK3 expression (median DFS = 21 months; range 1–90 months; p = 0.01) (Figure 3b). This evidence concerns the gene MAP3K3 and esophageal squamous cell carcinoma.