MAP3K3 and dysplasia: Notably, significant increase in cytoplasmic/nuclear localization of MEKK3 was observed in 34 of 61 (55.7%) dysplasia cases (p < 0.001, odd’s ratio (OR) = 4.6, 95% CI = 1.9-11.0) compared to normal esophageal tissues [Table 1 and Figure 1 (ii)].