Furthermore, ectopic expression of anti-miR-21 oligonucleotides renders HCC cells sensitive to IFN-α/5-FU, and similar results can be achieved by transfection of siRNAs against phosphatase and tensin homologue (PTEN) or programmed cell death 4 (PDCD4), two bona fide targets for miRN-21 [83]. This evidence concerns the gene PDCD4 and hepatocellular carcinoma.