IL17A and neoplasm: On the other hand, because IL-17 may serve as a promising biomarker with certain prognostic significance and potential clinical application prospect, further studies that focus on IL-17 regulation mechanism and the interaction between IL-17, cancer cells, mesenchymal cells, and immune cells in tumor microenvironment are expected to shed more light both on the exact biological function of IL-17 in CRC development and the clinical applications of IL-17-targeted treatment.