For example, myocardial SDF-1 expression was increased only during the early post-infarct phase, and as a result only MSCs intravenously infused in temporal vicinity to the early phase of myocardial infarction were recruited to injured myocardium, enhancing angiogenesis and improving cardiac function; further, MSCs injected when the cardiac SDF-1 expression had already fallen did not home to the heart or have a positive effect on the outcome [137]. Here, CXCL12 is linked to myocardial infarction.