AKT1 and type 2 diabetes mellitus: In addition, a defective and less active Akt-related pathway does not provide an efficient protection from apoptotic injuries, which may become a contributing factor in the pathogenesis and/or clinical progression of several human maladies, such as neurodegenerative diseases [37–41], illnesses of the cardiovascular system [42–45], and type-2 diabetes [33, 34, 46].