Inflammation and oxidative stress play an important role in obesity-induced renal damage; hence, we performed western blot assay for the renal expression of inflammatory cytokines, tumor necrosis factor-alpha (TNF-α, Figure 3(a)), and plasminogen activator inhibitor-1 (PAI-1, Figure 3(b)), which were also well accepted as adipocytokines or adipokines [18]. This evidence concerns the gene SERPINE1 and obesity due to melanocortin 4 receptor deficiency.