IL6 and Bilateral tonic-clonic seizure: Lehtimäki et al. [19] reported that the increased IL-6 levels in the cerebrospinal fluid (CSF) and serum following seizures were greater in recurrent generalized tonic-clonic seizure (GTS) patients than those in either single GTS or prolonged partial seizure patients; therefore, they concluded that seizures could induce cytokine production and that the CSF and serum IL-6 levels might correlate with the severity of a seizure.