PTGS2 and Parkinson disease: The compound 11b, i.e. 1-(Phenyl)-5-(4-methylsulfonylphenyl)-2-ethylthioimidazole, was used to find a relationship between striatum dopaminergic neurotransmission changes and drug induced catalepsy as PD and neuroleptic overdosage animal models after selective COX-2 inhibition.