We further explored the relationships between individual brain aging and clinically significant lifestyle risk factors (i.e., smoking duration, alcohol intake), clinical laboratory data [i.e., fasting blood glucose level as a potential indicator of hyperglycemia, tumor necrosis factor alpha (TNFα) as a potential indicator of persistent inflammation], and common clinical outcomes (i.e., cognition, depression). The gene discussed is TNF; the disease is Hyperglycemia.