Genes in this pathway related to motor neuron degeneration in ALS (KEGG:05014), and included SOD1, caspases 1,3,9, neurofilament light, medium and heavy (NFL, NFM and NFH), and N-methyl-D-Aspartate receptors GRIN 1, 2A, 2B, 2C and 2D. In addition, an ontology analysis based upon individual genes identified changes in pathways related to DNA metabolism, RNA splicing, mitochondrial function, oxidation, endoplasmic reticulum,ubiquitin proteasome system, post-transcriptional modification and neurological function. Here, SOD1 is linked to amyotrophic lateral sclerosis.