NFKB1 and neurodegenerative disease: Their findings could be summarized into: a) generation of NO was regulated through inhibition of JNK, p38 and NFκB signaling pathway, and b) compared to other macrophages and cell lines in brain, the concentration and inhibitory effect of curcumin in primary microglia cells is predominant, thus implying the potential therapeutic application of this compound in neurodegeneration diseases associated with inflammation.