SNCA and Parkinson disease: The focus of PD pathology is firmly entrenched in the aggregation of α-synuclein based on the following evidences accumulated over the years: a) autosomal dominant early-onset of PD occurred as a result of missense mutations in the α-synuclein gene or over-expression of wild type α-synuclein [329-331], b) the accumulation of α-synuclein in transgenic mice exhibited PD-like symptoms including motor impairment and inclusions [332], c) the deposits of α-synuclein were shown to be systemically detected in Lewy bodies and in animal models that were exposed to various neurotoxic compounds.