It is especially intriguing that during parasite infection, both enzymes are found in the human (DPAP1 is found in human red blood cells infected with P. falciparum parasite, while human cathepsin C is a lysosomal protease), and therefore molecules designed to specifically reach the DPAP1 active site must significantly differentiate between human and parasite orthologs. Here, CTSC is linked to parasitic infectious disease.