The activation of SIRT1 exertscytoprotective effects through multiple mechanisms, such asantiapoptosis, antioxidative, and anti-inflammation effects and the regulation of mitochondrial biogenesis, autophagy, and metabolism in response to the cellular energy and redox status[10].Resveratrol has been shown to be aSIRT1 activator [11], andnumerous previous studieshave shown that the administration of resveratrol can prevent many diseases, such as diabetes, neurodegenerative disorders, cognitive disorders, cancer, kidney diseases, and cardiovascular disease through SIRT1 activation [9, 10, 12]. The gene discussed is SIRT1; the disease is Cognitive impairment.