SIRT1 and diabetic kidney disease: Kim et al. demonstrated that resveratrol prevents diabetic nephropathy in db/db mice by the phosphorylation of AMPK and SIRT1-peroxisome proliferator-activated receptor γ coactivator (PGC)-1α signaling, which appear to prevent lipotoxicity-related mesangial cell apoptosis and oxidative stress in the kidney [34].