ALB and diabetes mellitus: Chen et al. reported that resveratrol treatment improved diabetes-induced glomerular hypertrophy and urinary albumin excretion;reduced the expression ofglomerular fibronectin, collagen IV, and transforming growth factor (TGF)-β; reduced the thickness of the glomerular basement membrane; and reduced nephrin expression in the kidneys of STZ-induced diabetic rats, possibly through the inhibition of the phosphorylation of Smad2, Smad3, and ERK1/2 [41].