In conclusion, ATA could not only induce tumor cells into apoptosis through the activation of both extrinsic and intrinsic pathways and arrest HepG2 cells in G2/M phase mediating p53 approach but also suppress the invasion and metastasis abilities of HepG2 cells by altering the expression of angiogenesis-relative genes and downregulating the expression level of MMP-9, PLAU, and S100A4 mRNA. The gene discussed is S100A4; the disease is neoplasm.