It also was reported that photodynamic therapy (PDT) could inhibit the MDR activity by downregulating the expression of P-glycoprotein via JNK activation using pheophorbide a (Pa) as the photosensitizer, and Pa-PDT inhibited the growth of MDR hepatoma cells by mitochondrial-mediated apoptosis induction [48]. Here, MAPK8 is linked to hepatocellular carcinoma.