Further supporting the concept that NK receptors other than NKG2C can contribute to shape NK cell receptor repertoire, following HCMV infection, is a study reporting the expansion of NKG2A−NKG2C− NK subsets expressing activating KIRs in a cohort of HCMV seropositive healthy individuals (51). This evidence concerns the gene KLRC2 and cytomegalovirus infection.