The optimal non-clinical sets obtained from the analysis of 24 h (α1, tau1_p001, s_pW111, Shannon_pW332, m_pTH5) and first 30 min (LF/HF, tau1_p001, SPPA_entropy, SPPA_r_5, m_ST_PEAK) NN interval time series revealed a similar AUC and PPA when compared to the optimal clinical parameter set (NYHA, NT-ProBNP, BMI, LVSD, LVEF). This evidence concerns the gene NPPB and hydrops fetalis.