SOD1 and amyotrophic lateral sclerosis: Interestingly, both D3H5 (Gros-Louis et al., 2010) and C4F6 (Brotherton et al., 2012) immunoreactivity for SOD1 G93A directly correlates with disease progression in the transgenic SOD1 G93A ALS mouse model, indicating that these antibodies report on the presence of “toxic,” misfolded forms of SOD1 G93A.