SOD1 and amyotrophic lateral sclerosis: Mutant-SOD1 transgenic mice develop an ALS-like phenotype that includes motor neuron degeneration, neuroinflammation, severe paralysis and premature death (Gurney et al., 1994; Dal Canto and Gurney, 1995; Wong et al., 1995; Bruijn et al., 1997; Dal Canto and Gurney, 1997).