That metal deficient WT SOD1 can be induced to misfold and exhibit a toxic nature analogous to FALS-linked SOD1 is supported by the immunization trial in ALS mice reported by Takeuchi et al. Low copy SOD1 G93A transgenic mice vaccinated with the apo WT SOD1 immunogen exhibited delayed disease onset and prolonged survival compared to control mice injected with saline/adjuvant, and importantly, to a similar degree as mice vaccinated with apo SOD1 G93A (Takeuchi et al., 2010). Here, SOD1 is linked to amyotrophic lateral sclerosis.