SOD1 and amyotrophic lateral sclerosis: For example, the conformation specific antibodies B8H10, D3H5, and A5C3 that were generated against apo-SOD1 G93A do not immunoprecipitate WT SOD1, but rather exhibit differential reactivity for various mutant-SOD1 proteins (G93A, G37R, G85R, G127X, and D90A) from spinal cord lysates derived from the respective ALS mouse models.