At the initial stages of CKD, mostly as a result of disorders of the plasma coagulation system and fibrinolysis (e.g., decreased levels of protein C and antithrombin III, elevated concentrations of fibrinogen, von Willebrand factor, factor VIII, elevated concentration of plasminogen activator inhibitor-1 (PAI-1), decreased concentration of tissue plasminogen activator (t-PA)), prothrombotic processes, clinically expressed as hypercoagulation, dominate [8, 9]. The gene discussed is SERPINE1; the disease is chronic kidney disease.