NFKB1 and neoplasm: The effects of RTX-A on the activity of proteins (AP-1, NF-κB) activating the expression of genes involved in tumor progression [170,171] were also studied in JB6 P+ Cl41 cells showing the time- and dose-dependent inhibition (10%–60%) of basal AP-1- and NF-κB-dependent transcriptional activity at concentrations 0.1–1.6 nM.