Caspase 1 activation can also inactivate sirtuin 1 (SIRT1) by cleavage [47], where SIRT1 is a NAD+-dependent protein deacetylase with anti-inflammatory properties [48,49,50,51,52], and it is recognized to protect against obesity-induced hepatic steatosis and inflammation [48,53,54,55,56]. The gene discussed is SIRT1; the disease is obesity due to melanocortin 4 receptor deficiency.