XRCC4 and neoplasm: We found that XRCC4 codon 247 polymorphism shortened MST of DIA (14 months for XRCC4-AS and 8 months for XRCC4-SS) and increased death risk of DIA (HRs were 2.26 and 5.36 for XRCC4-AS and -SS, respectively), possibly because it correlates with the fact that this polymorphism modifies tumor grade and differentiation, and, consequently, might promote tumor metastasis.