It has been recognized that fascin1 binds to β-catenin at leading cell edges and cell-cell border as a novel target of β-catenin-TCF signaling, supporting its role in modulating the functions of cell motility and adhesion and fascin1 expression is tightly regulated during development of colon cancer metastasis (16). The gene discussed is HNF4A; the disease is malignant colon neoplasm.