For example, mice with the knock-in mutant p53 R172H and R270H, which correspond to human p53 R175H and R273H mutations, develop a variety of novel tumors such as lung adenocarcinoma, renal cancer, hepatocellular carcinoma, and intestinal carcinoma which are not generally observed in TP53-null mice (17). This evidence concerns the gene TP53 and renal carcinoma.