KLF6 may also play a more generalized role in tumorigenenesis as a tumor suppressor gene that is inactivated in a number of human cancers by loss of heterozygosity (LOH) [5], somatic mutation, promoter hypermethylation [6] decreased expression [7] and increased alternative splicing into a dominant negative oncogenic splice variant, KLF6-SV1 [8]. This evidence concerns the gene KLF6 and cancer.