However, KLF6 mRNA half life greatly decreases in HCC-derived cell lines (t1/2 = 0.68 h for Hep3B, t1/2 = 0.82 h for HepG2) as compared to normal human hepatocytes (t1/2 = 1.05 h for IHH). The gene discussed is KLF6; the disease is hepatocellular carcinoma.