Therefore, the major focus of this study is to identify whether UPR activation in P23H RHO photoreceptors is accompanied by changes in Ca2+-induced signaling, autophagy, and mTOR/AKT pathways during ADRP progression and whether alterations in mTOR cellular signaling could be responsible for slowing the rate of retinal degeneration. Here, RHO is linked to retinal degeneration.