TGFB1 and familial pancreatic carcinoma: The non-malignant pancreatic ductal epithelial cell line H6c7 as well as the PDAC cell lines Panc-1 and Colo357 were particularly suitable because i) their TGF-β1-responsiveness is well characterized, ii) all cell lines respond to TGF-β1 with cell migration in vitro [21, 22] and iii) they were frequently employed in animal models for assessing the therapeutic activities of TGF-β inhibitors for suppressing pancreatic cancer growth and metastasis [23-25].