In contrast to the studies described above demonstrating IL-24 induced autophagy facilitated cell killing, Yang et al. using a conditionally replicating adenovirus (ZD55) reported exogenous expression of IL-24 in chronic lymphocytic leukemia B-cells induced autophagy via upregulation of beclin-1 that promoted cell survival [63]. Here, IL24 is linked to B-cell chronic lymphocytic leukemia.