We and others showed enforced expression of IL-24 in tumor cells resulted in accumulation of IL-24 protein in the endoplasmic reticulum (ER) that lead to activation of the unfolded protein response (UPR) and expression of molecular chaperones such as glucose-regulated protein (GRP) 78/immunoglobulin binding protein (BiP) [53,54]. This evidence concerns the gene HSPA5 and neoplasm.