Ucisik-Akkaya et al. (56) examined functional polymorphisms in three HSP genes that reside in the class III region: HSPA1L, HSPA1A, and HSPA1B. Among 114 ALL cases and 414 controls from the UK, they found that rs1061581, in HSPA1B, was significantly associated with childhood ALL risk. This evidence concerns the gene HSP90B2P and acute lymphoblastic leukemia.