HSPA1A and acute lymphoblastic leukemia: Ucisik-Akkaya et al. (56) examined functional polymorphisms in three HSP genes that reside in the class III region: HSPA1L, HSPA1A, and HSPA1B. Among 114 ALL cases and 414 controls from the UK, they found that rs1061581, in HSPA1B, was significantly associated with childhood ALL risk.