A set of genes including PRPF38A, RIOK3, QSER1, PSMC3IP, ATAD3B, MGC12982, and C20ORF27 were significantly overexpressed in HCC-R tumor tissue with fold changes ≥4 (P = 0.001 to 0.0001). The gene discussed is RIOK3; the disease is hepatocellular carcinoma.