CXCR4 and systemic sclerosis: Our data show that serum from SSc patients promotes the protein expression of chemokine (C-C motif) ligand 20 (CCL-20), chemokine (C-X-C motif) receptor 4 (CXCR-4), intercellular adhesion molecule 1 (ICAM-1), and vascular cell adhesion molecule 1 (VCAM-1) in HUVECs and that neutralization of IL-17A in culture medium suppressed the expression of these chemokines and adhesion molecules (Figure 2).