In line with the findings on NCF1, in our recent microarray based methylation study aimed at the identification of genes hypermethylated exclusively in cHL cell lines but not in normal mature B-cell or in other B-cell lymphomas we observed hypermethylation of the NCF1 gene in all five cHL cell lines studied namely L428, HDLM2, KMH2, L1236 and UHO1 [16]. Here, NCF1 is linked to classic Hodgkin lymphoma.