FMO5 and chronic granulomatous disease: In line with this observation, genetic defects in any of the NADPH oxidase genes cause impaired functionality of phagocytes, immunodeficiency and manifest in chronic granulomatous disease characterized by recurrent and severe infections including pneumonia, infectious dermatitis or osteomyelitis (Online Mendelian Inheritance in Man database - OMIM): CYBA 233690, CYBB 306400, NCF1 233700, NCF2 233710, NCF4 613960) [2,3].