Time activity curves of 11C-MET, 18F-FET and 18F-FDG were compared in various human myeloma cell lines and correlated to hallmarks of MM biology, including levels of immunoglobulin (Ig) light chains, proliferation rate, as well as CD138 and CXCR4 expression. This evidence concerns the gene CXCR4 and Miyoshi myopathy.